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Bone cancer
Thu,09 February 2012 BONE CANCER develops most often in young people aged 10-20 years. Unlike almost all other "painless" types of cancer early symptom of bone cancer is usually a pain.
Sometimes the
Soy allergy
Sat,11 February 2012
Soy allergy affects approximately 1 percent of people in the United States. Soy, also called soya, is among the top eight most common foods that trigger allergies in children. In many cases soy
How to boost your 'good' cholesterol
Wed,01 February 2012 Your doctor says you need to lower your low-density lipoprotein (LDL) cholesterol, what's often called the "bad" cholesterol. You're working hard at that goal, but now your doctor says it
What is type 2 diabetes?
Sun,29 January 2012 Type 2 diabetes is a lifelong disease that happens when the cells of the body can't use insulin the right way or when the pancreas can't make enough insulin. Insulin lets blood sugar—also cal
Managing Your Diabetes Risk
Fri,27 January 2012 By now, most people know that diabetes is a significant and growing public health problem. Here are some of the major risk factors for this disorder, along with some tips you can put into play righ
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Development of stomach cancer
A group led by Columbia University Medical Center's Timothy Wang, M.D., has studied the role of Helicobacter infection in the development of stomach cancer and found that the hormone gastrin, which stimulates secretion of gastric acid, plays a key role in the development of Helicobacter-induced stomach cancer, and may have distinct effects on carcinogenesis in different parts of the stomach. More than 50 % of the world's population is infected with Helicobacter, which causes chronic inflammation of the stomach lining and is strongly linked to the development of gastric ulcers and stomach cancer. Stomach cancer is the second leading cause of cancer-related deaths worldwide.
Helicobacter infection results in increased expression of gastrin, although its role in cancer development has been unclear. High levels of gastrin lead to the development of stomach cancer, but absence of gastrin has been shown to increase the numbers of tumors in the gastric antrum, the lower section of the stomach that empties into the small intestine.
To reconcile this apparent incongruity, a group led by Dr. Wang studied Helicobacter infection and stomach cancer in animal models with either high expression of gastrin or no gastrin at all. They found that Helicobacter infection in mice with high levels of gastrin resulted in cancer of the gastric corpus (main body of the stomach), whereas infection in gastrin-deficient mice developed cancer in the gastric antrum. Online Pharmacy provides the access to health information and prescription medications.
Dr. Wang argue that gastrin may serve as a "rheostat" for the stomach. Gastrin likely plays a central role in the safety network for the protection from mucosal damage caused by gastric acid secretion induced by gastrin itself, and thus either too much or too little gastrin could predispose a person to stomach cancer. Therefore, clinicians in the future may need to be more careful about prescribing acid-suppressive drugs for long-term use in patients infected with Helicobacter, Dr. Wang says.
In future studies, Dr. Wang and colleagues plan to study "host factors other than gastrin that are also important for Helicobacter-associated gastric carcinogenesis." These include specific cytokines and chemokines induced by Helicobacter infection and modulated by gastrin, that link inflammation and cancer. In addition, they plan to study the role of other non-Helicobacter bacteria that colonize the stomach when acid secretion is suppressed, since bacterial overgrowth likely contributes to gastric carcinogenesis.
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